Yearly Archives: 2023

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Resistencia a ceftazidima/avibactam, meropenem/vaborbactam e imipenem/relebactam en bacilos gramnegativos MDR: mecanismos moleculares y pruebas de susceptibilidad.[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Gaibani, P.; Giani, T.; Bovo, F.; Lombardo, D.; Amadesi, S.; Lazzarotto, T.; Coppi, M.; Rossolini, G.M.; Ambretti, S. Resistance to Ceftazidime/Avibactam,
Meropenem/Vaborbactam and Imipenem/Relebactam in Gram-Negative MDR Bacilli: Molecular Mechanisms and Susceptibility Testing. Antibiotics
2022, 11, 628. https://doi.org/ 10.3390/antibiotics11050628

[/text-with-icon][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]La resistencia a múltiples medicamentos (MDR) representa una grave amenaza global debido a la rápida propagación global y las limitadas opciones antimicrobianas para el tratamiento de infecciones difíciles de tratar (DTR). Recientemente, se han desarrollado nuevas combinaciones de β-lactámicos/inhibidores de β-lactamasa (βL-INH) para el tratamiento de infecciones por DTR debidas a patógenos gramnegativos MDR. Aunque los nuevos βL-INH mostraron actividades prometedoras in vitro e in vivo contra patógenos MDR, recientemente se han informado resistencias emergentes a estas nuevas moléculas. Esta resistencia se debe a varios mecanismos que incluyen deficiencias de porinas, aumento de la expresión de carbapenemasas y/o mutaciones enzimáticas. En esta revisión, se resumen los principales mecanismos relacionados con la resistencia a ceftazidima/avibactam, meropenem/vaborbactam e imipenem/relebactam en MDR. Los autores se enfocan en los mecanismos moleculares relacionados con la resistencia a estos nuevos fármacos, discuten sobre los principales métodos de detección y las pruebas de susceptibilidad de estos antimicrobianos.[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="3198" animation="Fade In" hover_animation="none" alignment="" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" text_color="#000000" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.mdpi.com/2079-6382/11/5/628"][/vc_column][/vc_row]

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Staphylococcus aureus:

Interacciones y adaptación del huésped.

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Howden, B.P., Giulieri, S.G., Wong Fok Lung, T. et al. Staphylococcus aureus host interactions and adaptation. Nat Rev Microbiol (2023). https://doi.org/10.1038/s41579-023-00852-y

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Staphylococcus aureus es un excelente ejemplo del potencial de una bacteria para ser comensal, colonizante o causante de enfermedades en distintas especies de seres vivos, con una amplia plasticidad genómica.

Este estudio revisa el papel principal de los neutrófilos en el control de la infección, el descubrimiento de nuevas moléculas de evasión inmune y de recientes funciones atribuidas a factores de virulencia, explora la intersección del metabolismo bacteriano y del huésped, el rol de las biopelículas de S. aureus, las variantes de colonias pequeñas de S. aureus y el flujo de genes en diferentes nichos ecológicos, como parte de la comprensión de la adaptación del huésped.

Con su capacidad para cambiar entre especies huésped, pasar de la colonización a la invasión o desarrollar resistencia y persistencia a los antibióticos, S. aureus tiene la propensión a adaptarse a nuevos entornos. Una comprensión integrada de cómo la genómica, la evolución y la adaptación de S. aureus se cruzan con las estrategias de virulencia y evasión inmunitaria guiará el diseño de estrategias de prevención y enfoques terapéuticos.

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