Tag Archives: betalactamasa

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Resistencia a betalactámicos en Pseudomonas aeruginosa : estado actual, perspectivas futuras

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Glen, K. A., & Lamont, I. L. (2021). β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects. Pathogens (Basel, Switzerland), 10(12), 1638. https://doi.org/10.3390/pathogens10121638

[/text-with-icon][vc_column_text]La resistencia a los betalactámicos es multifactorial y puede implicar cambios en una proteína diana clave (PBP3), la reducción de la captación o el aumento del flujo de salida de betalactámicos, la degradación de éstos por aumento de la expresión o alteración de la especificidad de sustrato de la β-lactamasa AmpC y otras enzimas cromosómicas en P. aeruginosa, o por la adquisición de β-lactamasas a través de la transferencia horizontal de genes, así como los cambios en la formación de biopelículas y el metabolismo.

Este artículo facilita la comprensión actual de estos mecanismos y discute las posibles estrategias para mejorar la eficacia de los antibióticos betalactámicos en el tratamiento de infecciones por P. aeruginosa.[/vc_column_text][image_with_animation image_url="2977" animation="Fade In" hover_animation="none" alignment="center" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706265/"][/vc_column][/vc_row]

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Desarrollo de un algoritmo para discriminar entre la producción de β-lactamasa AmpC mediada por plásmidos y cromosomas en Escherichia coli, mediante una caracterización fenotípica y genotípica.

[/nectar_highlighted_text][vc_column_text]Para fines de control de infecciones, es importante poder discriminar entre la producción de AmpC mediada por plásmidos (pAmpC) y la hiperproducción de AmpC mediada por cromosomas (cAmpC) en bacterias Gram-negativas, ya que pAmpC requiere precauciones de aislamiento para minimizar el riesgo de transmisión horizontal de genes. La detección de pAmpC en Escherichia coli es un desafío, ya que tanto la producción de pAmpC como la hiperproducción de cAmpC pueden conducir a una resistencia a las cefalosporinas de tercera generación.

Este artículo presenta un algoritmo pragmático para diferenciar genotipos ampC en E. coli basado en pruebas de susceptibilidad fenotípica.[/vc_column_text][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Journal of Antimicrobial Chemotherapy  , volumen 74, número 12, diciembre de 2019, páginas 3481–3488, https://doi.org/10.1093/jac/dkz362

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