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[/text-with-icon][vc_column_text]La resistencia a los betalactámicos es multifactorial y puede implicar cambios en una proteína diana clave (PBP3), la reducción de la captación o el aumento del flujo de salida de betalactámicos, la degradación de éstos por aumento de la expresión o alteración de la especificidad de sustrato de la β-lactamasa AmpC y otras enzimas cromosómicas en P. aeruginosa, o por la adquisición de β-lactamasas a través de la transferencia horizontal de genes, así como los cambios en la formación de biopelículas y el metabolismo.
Este artículo facilita la comprensión actual de estos mecanismos y discute las posibles estrategias para mejorar la eficacia de los antibióticos betalactámicos en el tratamiento de infecciones por P. aeruginosa.[/vc_column_text][image_with_animation image_url="2977" animation="Fade In" hover_animation="none" alignment="center" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706265/"][/vc_column][/vc_row]
Resistencia a betalactámicos en Pseudomonas aeruginosa : estado actual, perspectivas futuras
[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]
Glen, K. A., & Lamont, I. L. (2021). β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects. Pathogens (Basel, Switzerland), 10(12), 1638. https://doi.org/10.3390/pathogens10121638
[/text-with-icon][vc_column_text]La resistencia a los betalactámicos es multifactorial y puede implicar cambios en una proteína diana clave (PBP3), la reducción de la captación o el aumento del flujo de salida de betalactámicos, la degradación de éstos por aumento de la expresión o alteración de la especificidad de sustrato de la β-lactamasa AmpC y otras enzimas cromosómicas en P. aeruginosa, o por la adquisición de β-lactamasas a través de la transferencia horizontal de genes, así como los cambios en la formación de biopelículas y el metabolismo.
Este artículo facilita la comprensión actual de estos mecanismos y discute las posibles estrategias para mejorar la eficacia de los antibióticos betalactámicos en el tratamiento de infecciones por P. aeruginosa.[/vc_column_text][image_with_animation image_url="2977" animation="Fade In" hover_animation="none" alignment="center" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706265/"][/vc_column][/vc_row]