Monthly Archives: febrero 2021

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]Int. J. Mol. Sci. 2020, 21, 9308; doi:10.3390/ijms21239308[/vc_column_text][nectar_highlighted_text color_type="regular" style="full_text"]

Nuevos inhibidores de carbapenemasas : mejorando la vía para los betalactámicos.

[/nectar_highlighted_text][vc_column_text]La resistencia a los carbapenémicos es un importante problema de salud mundial que compromete gravemente el tratamiento de infecciones causadas por patógenos nosocomiales. Se produce principalmente a través de la producción de carbapenemasas, como KPC, VIM, IMP, NDM, OXA, entre otras. Actualmente se están llevando a cabo ensayos clínicos para probar una nueva generación de inhibidores muy prometedores, junto con el avibactam, relebactam y vaborbactam recientemente aprobados.

Esta revisión resume los principales inhibidores de carbapenemasas más prometedores sintetizados hasta la fecha, así como su espectro de actividad y etapa actual de desarrollo. Este artículo se centra especialmente en las combinaciones de betalactámicos con inhibidores de betalactamasas que podrían usar para tratar infecciones causadas por patógenos productores de carbapenemasas de
prioridad crítica. La aparición de estas nuevas combinaciones supone un paso adelante en la lucha contra la resistencia a los antimicrobianos.[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/2" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="2601" animation="Fade In" hover_animation="none" alignment="right" img_link_large="yes" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/2" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="2602" animation="Fade In" hover_animation="none" alignment="right" img_link_large="yes" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="see-through" heading_tag="h6" button_color="default" link_type="regular" alignment="left" display="block" text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731173/"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

La base de metadatos de diversidad bacteriana Bac Dive (http://bacdive.dsmz.de ) se ha convertido en un recurso completo de datos estructurados sobre taxonomía, morfología, fisiología, cultivo, aislamiento y datos moleculares de procariotas.

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="2/3" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]Proporciona una amplia gama de cepas de bacterias y arqueas. Las fuentes primarias son bases de datos internas de BRC, colecciones de investigadores y descripciones de especies.

Actualmente cuenta con más de 82000 cepas y más de 14000 especies.

Al acceder a estas fuentes, BacDive proporciona conjuntos de datos completos y moleculares de las procariotas. Todos están asociados a la cepa y relacionados con:



[/vc_column_text][vc_column_text]Referencias:

-Nucleic Acids Research, Volumen 47, Edición D1, 08 de enero de 2019, Páginas D631 - D636, https://doi.org/10.1093/nar/gky879. En: https://academic.oup.com/nar/article/47/D1/D631/5106998

-LPSN Lista de nombres procarióticos con posición en la nomenclatura. En: https://lpsn.dsmz.de/

-Nuevo lanzamiento de Bac Dive. En: https://bacdive.dsmz.de/news[/vc_column_text][/vc_column][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/3" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]En el siguiente enlace encuentras los tutoriales para optimizar su uso, en las diferentes secciones: https://bacdive.dsmz.de/tutorials

• Inicio rápido


• Búsqueda avanzada


• Buscador de tira de prueba API


• Funciones de exportación


• Búsqueda de fuente de aislamiento

[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

Desarrollo de un algoritmo para discriminar entre la producción de β-lactamasa AmpC mediada por plásmidos y cromosomas en Escherichia coli, mediante una caracterización fenotípica y genotípica.

[/nectar_highlighted_text][vc_column_text]Para fines de control de infecciones, es importante poder discriminar entre la producción de AmpC mediada por plásmidos (pAmpC) y la hiperproducción de AmpC mediada por cromosomas (cAmpC) en bacterias Gram-negativas, ya que pAmpC requiere precauciones de aislamiento para minimizar el riesgo de transmisión horizontal de genes. La detección de pAmpC en Escherichia coli es un desafío, ya que tanto la producción de pAmpC como la hiperproducción de cAmpC pueden conducir a una resistencia a las cefalosporinas de tercera generación.

Este artículo presenta un algoritmo pragmático para diferenciar genotipos ampC en E. coli basado en pruebas de susceptibilidad fenotípica.[/vc_column_text][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Journal of Antimicrobial Chemotherapy  , volumen 74, número 12, diciembre de 2019, páginas 3481–3488, https://doi.org/10.1093/jac/dkz362

[/text-with-icon][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="2538" animation="Fade In" hover_animation="none" alignment="center" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][divider line_type="No Line" custom_height="65"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="see-through" heading_tag="h6" button_color="default" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://academic.oup.com/jac/article/74/12/3481/5554444"][/vc_column][/vc_row]