Category Archives: blog

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Estado actual del cassette cromosómico estafilocócico o SCCmec.

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Uehara Y. Current Status of Staphylococcal Cassette Chromosome mec (SCCmec). Antibiotics. 2022; 11(1):86. https://doi.org/10.3390/antibiotics11010086

[/text-with-icon][vc_column_text]En esta revisión se resumió el estado actual de los tipos de SCC mec , los subtipos de SCC mec , las reglas de nomenclatura y los múltiples métodos para identificar los tipos y subtipos de SCC mec , según la perspectiva del Grupo de Trabajo Internacional sobre la Clasificación de Elementos Cromosómicos en Cassette de Estafilococos.[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" text_color="#000000" link_type="regular" alignment="left" display="block" url="https://www.mdpi.com/2079-6382/11/1/86" link_text="Artículo completo"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

Resistencia a ceftazidima/avibactam, meropenem/vaborbactam e imipenem/relebactam en bacilos gramnegativos MDR: mecanismos moleculares y pruebas de susceptibilidad.[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Gaibani, P.; Giani, T.; Bovo, F.; Lombardo, D.; Amadesi, S.; Lazzarotto, T.; Coppi, M.; Rossolini, G.M.; Ambretti, S. Resistance to Ceftazidime/Avibactam,
Meropenem/Vaborbactam and Imipenem/Relebactam in Gram-Negative MDR Bacilli: Molecular Mechanisms and Susceptibility Testing. Antibiotics
2022, 11, 628. https://doi.org/ 10.3390/antibiotics11050628

[/text-with-icon][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]La resistencia a múltiples medicamentos (MDR) representa una grave amenaza global debido a la rápida propagación global y las limitadas opciones antimicrobianas para el tratamiento de infecciones difíciles de tratar (DTR). Recientemente, se han desarrollado nuevas combinaciones de β-lactámicos/inhibidores de β-lactamasa (βL-INH) para el tratamiento de infecciones por DTR debidas a patógenos gramnegativos MDR. Aunque los nuevos βL-INH mostraron actividades prometedoras in vitro e in vivo contra patógenos MDR, recientemente se han informado resistencias emergentes a estas nuevas moléculas. Esta resistencia se debe a varios mecanismos que incluyen deficiencias de porinas, aumento de la expresión de carbapenemasas y/o mutaciones enzimáticas. En esta revisión, se resumen los principales mecanismos relacionados con la resistencia a ceftazidima/avibactam, meropenem/vaborbactam e imipenem/relebactam en MDR. Los autores se enfocan en los mecanismos moleculares relacionados con la resistencia a estos nuevos fármacos, discuten sobre los principales métodos de detección y las pruebas de susceptibilidad de estos antimicrobianos.[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="3198" animation="Fade In" hover_animation="none" alignment="" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" text_color="#000000" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.mdpi.com/2079-6382/11/5/628"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

Staphylococcus aureus:

Interacciones y adaptación del huésped.

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Howden, B.P., Giulieri, S.G., Wong Fok Lung, T. et al. Staphylococcus aureus host interactions and adaptation. Nat Rev Microbiol (2023). https://doi.org/10.1038/s41579-023-00852-y

[/text-with-icon][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]

Staphylococcus aureus es un excelente ejemplo del potencial de una bacteria para ser comensal, colonizante o causante de enfermedades en distintas especies de seres vivos, con una amplia plasticidad genómica.

Este estudio revisa el papel principal de los neutrófilos en el control de la infección, el descubrimiento de nuevas moléculas de evasión inmune y de recientes funciones atribuidas a factores de virulencia, explora la intersección del metabolismo bacteriano y del huésped, el rol de las biopelículas de S. aureus, las variantes de colonias pequeñas de S. aureus y el flujo de genes en diferentes nichos ecológicos, como parte de la comprensión de la adaptación del huésped.

Con su capacidad para cambiar entre especies huésped, pasar de la colonización a la invasión o desarrollar resistencia y persistencia a los antibióticos, S. aureus tiene la propensión a adaptarse a nuevos entornos. Una comprensión integrada de cómo la genómica, la evolución y la adaptación de S. aureus se cruzan con las estrategias de virulencia y evasión inmunitaria guiará el diseño de estrategias de prevención y enfoques terapéuticos.

[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="3165" animation="Fade In" hover_animation="none" alignment="" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.nature.com/articles/s41579-023-00852-y#Sec10"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

Pruebas de susceptibilidad a los antimicrobianos: una revisión exhaustiva de los métodos utilizados actualmente.

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Gajic I, Kabic J, Kekic D, Jovicevic M, Milenkovic M, Mitic Culafic D, Trudic A, Ranin L, Opavski N. Antimicrobial Susceptibility Testing: A Comprehensive Review of Currently Used Methods. Antibiotics (Basel). 2022 Mar 23;11(4):427. doi: 10.3390/antibiotics11040427. PMID: 35453179; PMCID: PMC9024665.

[/text-with-icon][vc_column_text]La resistencia a los antimicrobianos (RAM) se ha convertido en una importante amenaza para la salud pública a nivel mundial. La detección precisa y rápida de la resistencia a los medicamentos antimicrobianos y el posterior tratamiento antimicrobiano adecuado, combinados con la administración antimicrobiana, son esenciales para controlar la aparición y propagación de la RAM.

Este artículo revisa los métodos comunes de prueba de susceptibilidad a los antimicrobianos (AST) y los temas relevantes relacionados con las ventajas y desventajas de cada método. Con un aumento continuo de la RAM, se necesitan esfuerzos adicionales para desarrollar herramientas de diagnóstico innovadoras, rápidas y precisas en las AST. [/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="3078" animation="Fade In" hover_animation="none" alignment="" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024665/"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

Resistencia a betalactámicos en Pseudomonas aeruginosa : estado actual, perspectivas futuras

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Glen, K. A., & Lamont, I. L. (2021). β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects. Pathogens (Basel, Switzerland), 10(12), 1638. https://doi.org/10.3390/pathogens10121638

[/text-with-icon][vc_column_text]La resistencia a los betalactámicos es multifactorial y puede implicar cambios en una proteína diana clave (PBP3), la reducción de la captación o el aumento del flujo de salida de betalactámicos, la degradación de éstos por aumento de la expresión o alteración de la especificidad de sustrato de la β-lactamasa AmpC y otras enzimas cromosómicas en P. aeruginosa, o por la adquisición de β-lactamasas a través de la transferencia horizontal de genes, así como los cambios en la formación de biopelículas y el metabolismo.

Este artículo facilita la comprensión actual de estos mecanismos y discute las posibles estrategias para mejorar la eficacia de los antibióticos betalactámicos en el tratamiento de infecciones por P. aeruginosa.[/vc_column_text][image_with_animation image_url="2977" animation="Fade In" hover_animation="none" alignment="center" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="material" heading_tag="h6" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706265/"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

La necesidad urgente de inhibidores de metalo-β-lactamasa: una amenaza global desatendida.

[/nectar_highlighted_text][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]Lomovskaya O, Tsivkovski R, Sun D, Reddy R, Totrov M, Hecker S, Griffith D, Loutit J, Dudley M. QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics. Front Microbiol. 2021 Jul 5;12:697180. doi: 10.3389/fmicb.2021.697180.[/text-with-icon][vc_column_text]La resistencia a los carbapenémicos entre las Gram negativas se debe principalmente a la producción de carbapenemasas, a través de dos tipos de enzimas: una basada en un residuo de serina (serina β-lactamasas) y otra que usa uno o dos iones de zinc ( metalo-β-lactamasas).

Las metalo-β-lactamasas son de particular interés y preocupación dados varios factores:

(1) Su capacidad para hidrolizar y proporcionar resistencia a prácticamente todos los antibióticos β-lactámicos

(2) La falta de disponibilidad de inhibidores de metalo-β-lactamasa clínicamente útiles

(3) El rápido ritmo al que se aíslan las nuevas variantes

(4) La transferibilidad de sus genes codificantes

(5) Su ubicuidad, porque están aislados de fuentes nosocomiales y ambientales.

Se dividen a su vez en tres subclases (B1, B2 y B3), con base principalmente en su contenido metálico y las diferentes características del sitio activo. La mayoría de las metalo-β-lactamasas que se han identificado hasta ahora pertenecen a la subclase B1, entre las que se encuentran la imipenemasa (IMP), la imipenemasa de Verona (VIM) y las metalo-β-lactamasas de Nueva Delhi ( NDM) son las tres familias más comunes. La subclase B2 tiene la menor cantidad de miembros e incluye enzimas producidas por diferentes especies de  Aeromonas  , como  A hydrophila, A veronii  y  Serratia fonticola  (la enzima se denomina en la literatura como CphA, ImiS y Sfh-I, respectivamente).La subclase B3 incluye L1 de  Stenotrophomonas maltophilia.

Actualmente, los inhibidores clínicos aprobados para las metalo-β-lactamasas no están disponibles. Las metalo-β-lactamasas no comparten una relación evolutiva con las β-lactamasas de serina, porque estas β-lactamasas poseen estructuras diferentes, sitios activos y mecanismos catalíticos.

Este artículo resume los principales avances logrados en esta área de investigación, señala los principales desafíos que necesitan ser resueltos y la importancia de la investigación sobre inhibidores de metalo-B-lactamasas en medio de la pandemia actual.

[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="see-through" heading_tag="h6" button_color="default" link_type="regular" alignment="left" display="block" link_text="Artículo completo" url="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30868-9/fulltext"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

QPX7728, un inhibidor de betalactamasa de espectro ultra amplio para terapia intravenosa y oral: descripción general de las características bioquímicas y microbiológicas

[/nectar_highlighted_text][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]Maria F Mojica, Maria-Agustina Rossi, Alejandro J Vila, Robert A Bonomo. The urgent need for metallo-β-lactamase inhibitors: an unattended global threat. The Lancet Infectious Diseases ( IF 25.071 ) Pub Date : 2021-07-08 , DOI: 10.1016/s1473-3099(20)30868-9.[/text-with-icon][vc_column_text]QPX7728 es un nuevo inhibidor de la β-lactamasa (BLI) que pertenece a una clase de boronatos cíclicos. El primer miembro de esta clase, vaborbactam, es un BLI en el Vabomere (meropenem-vaborbactam) recientemente aprobado.

Además de la potente inhibición de serina β-lactamasas clínicamente importantes, incluidas las carbapenemasas de Clase A y D de Enterobacterales y, en particular, diversas carbapenemasas de Clase D de Acinetobacter, también inhibe muchas metalo β-lactamasas.

Este artículo muestra una descripción general de los estudios bioquímicos, estructurales y microbiológicos que se llevaron a cabo recientemente con QPX7728.[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="see-through" heading_tag="h6" button_color="default" link_type="regular" alignment="left" display="block" url="https://www.frontiersin.org/articles/10.3389/fmicb.2021.697180/full" link_text="Artículo completo"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]Int. J. Mol. Sci. 2020, 21, 9308; doi:10.3390/ijms21239308[/vc_column_text][nectar_highlighted_text color_type="regular" style="full_text"]

Nuevos inhibidores de carbapenemasas : mejorando la vía para los betalactámicos.

[/nectar_highlighted_text][vc_column_text]La resistencia a los carbapenémicos es un importante problema de salud mundial que compromete gravemente el tratamiento de infecciones causadas por patógenos nosocomiales. Se produce principalmente a través de la producción de carbapenemasas, como KPC, VIM, IMP, NDM, OXA, entre otras. Actualmente se están llevando a cabo ensayos clínicos para probar una nueva generación de inhibidores muy prometedores, junto con el avibactam, relebactam y vaborbactam recientemente aprobados.

Esta revisión resume los principales inhibidores de carbapenemasas más prometedores sintetizados hasta la fecha, así como su espectro de actividad y etapa actual de desarrollo. Este artículo se centra especialmente en las combinaciones de betalactámicos con inhibidores de betalactamasas que podrían usar para tratar infecciones causadas por patógenos productores de carbapenemasas de
prioridad crítica. La aparición de estas nuevas combinaciones supone un paso adelante en la lucha contra la resistencia a los antimicrobianos.[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/2" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="2601" animation="Fade In" hover_animation="none" alignment="right" img_link_large="yes" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/2" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][image_with_animation image_url="2602" animation="Fade In" hover_animation="none" alignment="right" img_link_large="yes" border_radius="none" box_shadow="none" image_loading="default" max_width="100%" max_width_mobile="default"][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_cta btn_style="see-through" heading_tag="h6" button_color="default" link_type="regular" alignment="left" display="block" text="Artículo completo" url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731173/"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

La base de metadatos de diversidad bacteriana Bac Dive (http://bacdive.dsmz.de ) se ha convertido en un recurso completo de datos estructurados sobre taxonomía, morfología, fisiología, cultivo, aislamiento y datos moleculares de procariotas.

[/nectar_highlighted_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="2/3" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]Proporciona una amplia gama de cepas de bacterias y arqueas. Las fuentes primarias son bases de datos internas de BRC, colecciones de investigadores y descripciones de especies.

Actualmente cuenta con más de 82000 cepas y más de 14000 especies.

Al acceder a estas fuentes, BacDive proporciona conjuntos de datos completos y moleculares de las procariotas. Todos están asociados a la cepa y relacionados con:



[/vc_column_text][vc_column_text]Referencias:

-Nucleic Acids Research, Volumen 47, Edición D1, 08 de enero de 2019, Páginas D631 - D636, https://doi.org/10.1093/nar/gky879. En: https://academic.oup.com/nar/article/47/D1/D631/5106998

-LPSN Lista de nombres procarióticos con posición en la nomenclatura. En: https://lpsn.dsmz.de/

-Nuevo lanzamiento de Bac Dive. En: https://bacdive.dsmz.de/news[/vc_column_text][/vc_column][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/3" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][vc_column_text]En el siguiente enlace encuentras los tutoriales para optimizar su uso, en las diferentes secciones: https://bacdive.dsmz.de/tutorials

• Inicio rápido


• Búsqueda avanzada


• Buscador de tira de prueba API


• Funciones de exportación


• Búsqueda de fuente de aislamiento

[/vc_column_text][/vc_column][/vc_row][vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][/vc_column][/vc_row]

[vc_row type="in_container" full_screen_row_position="middle" column_margin="default" column_direction="default" column_direction_tablet="default" column_direction_phone="default" scene_position="center" text_color="dark" text_align="left" row_border_radius="none" row_border_radius_applies="bg" overlay_strength="0.3" gradient_direction="left_to_right" shape_divider_position="bottom" bg_image_animation="none"][vc_column column_padding="no-extra-padding" column_padding_tablet="inherit" column_padding_phone="inherit" column_padding_position="all" background_color_opacity="1" background_hover_color_opacity="1" column_shadow="none" column_border_radius="none" column_link_target="_self" gradient_direction="left_to_right" overlay_strength="0.3" width="1/1" tablet_width_inherit="default" tablet_text_alignment="default" phone_text_alignment="default" column_border_width="none" column_border_style="solid" bg_image_animation="none"][nectar_highlighted_text color_type="regular" style="full_text"]

Desarrollo de un algoritmo para discriminar entre la producción de β-lactamasa AmpC mediada por plásmidos y cromosomas en Escherichia coli, mediante una caracterización fenotípica y genotípica.

[/nectar_highlighted_text][vc_column_text]Para fines de control de infecciones, es importante poder discriminar entre la producción de AmpC mediada por plásmidos (pAmpC) y la hiperproducción de AmpC mediada por cromosomas (cAmpC) en bacterias Gram-negativas, ya que pAmpC requiere precauciones de aislamiento para minimizar el riesgo de transmisión horizontal de genes. La detección de pAmpC en Escherichia coli es un desafío, ya que tanto la producción de pAmpC como la hiperproducción de cAmpC pueden conducir a una resistencia a las cefalosporinas de tercera generación.

Este artículo presenta un algoritmo pragmático para diferenciar genotipos ampC en E. coli basado en pruebas de susceptibilidad fenotípica.[/vc_column_text][text-with-icon icon_type="font_icon" icon="icon-book" color="Accent-Color"]

Journal of Antimicrobial Chemotherapy  , volumen 74, número 12, diciembre de 2019, páginas 3481–3488, https://doi.org/10.1093/jac/dkz362

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